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On a winter night during Christmas, Spider-Man is house-sitting Doctor Strange’s Sanctum Sanctorum who is away on a mission to save all of existence from some threat. During this time, he hears Moon Knight chasing a girl from outside. For her safety, Spider-Man allows her to enter the Sanctorum only to discover that she is Francis Beck, the daughter of his presumed deceased enemy Mysterio as she plans to attack Spider-Man upon claiming the Mysterio helmet from a restricted room in the Sanctum Sanctorum. Now Spider-Man must work with Moon Knight to defeat this female Mysterio.