The first five episodes of Loonatics Unleashed take place in 2772, the year that a meteor strikes the fictional city-planet of Acmetropolis, knocking it completely off its original axis. However, instead of destroying the planet, the impact of the meteor and its resultant shock wave gives off supernatural cosmic energies that give some inhabitants superpowers while incapacitating others. A mysterious and powerful woman called Zadavia calls upon six of the affected residents to form a team of superheroes. She becomes their supervisor, dispatching them for the purpose of combating any and all threats to Acmetropolis and its citizens. The newly formed team is known as the Loonatics and reside on the 125th floor of a large tower. These characters are the descendants of the classic Looney Tunes characters, according to multiple press releases and official sources. Descendants of other Looney Tunes are unverified, though implied.